Publication Details

Authors: Johan d’Humières, Lianzijun Wang, David R. Sherwood, Julie Plastino

Journal: bioRxiv preprint (posted March 13, 2025)

Year: 2025

DOI: 10.1101/2025.03.13.643012

PMID: 40161654

Abstract

The mechanical interaction between the actin cytoskeleton and the nucleus during invasion through basement membrane remains poorly characterized. Using C. elegans anchor cells, this study demonstrates that actin protrusions mechanically deform the nucleus to facilitate basement-membrane penetration. Imaging and mechanical analyses reveal that actin-based force generation at the invasive front produces transient nuclear deformations essential for invasion.

Keywords

actin protrusion, nuclear mechanics, basement membrane, cell invasion, C. elegans

Citation

d’Humières, J., Wang, L., Sherwood, D. R., & Plastino, J. (2025). The actin protrusion deforms the nucleus during invasion through basement membrane. bioRxiv. https://doi.org/10.1101/2025.03.13.643012

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