Publication Details
Authors: J. H. Bumm, D. D. Lee, Z. Qiu, A. H. Choi, M. Kolluri, M. J. Olsen, L. Wang, M. Lee
Journal: Developmental Dynamics
Year: 2024
PMID: 41117756
Abstract
Integrin, a heterodimeric receptor, recruits focal adhesion proteins through two cytoplasmic NPxY motifs. In C. elegans, PAT-3/β integrin NPxY phosphorylation mutants were analyzed. Non-phosphorylatable and phosphomimetic mutants revealed distinct effects on serotonin sensitivity, egg laying, and mechanosensation. The results show that phosphorylation state of NPxY motifs modulates neurotransmitter response and sensory behaviors, linking integrin signaling to neuronal activity.
Keywords
integrin, NPxY motif, serotonin, egg laying, mechanosensation, C. elegans
Citation
Bumm, J. H., Lee, D. D., Qiu, Z., Choi, A. H., Kolluri, M., Olsen, M. J., Wang, L., & Lee, M. (2024). The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in Caenorhabditis elegans. Developmental Dynamics. PMID: 41117756
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