An Integrin Binding Motif in TLN-1/Talin Plays a Minor Role in Motility and Ovulation

Publication Details

Authors: Fereshteh Sadeghian, Ibrahim Ibrahim, Lokesh Ravichandran, Grace Henderson, Anisha Acharya, Lianzijun Wang, Myeongwoo Lee, Erin J. Cram

Journal: microPublication Biology

Year: 2023

DOI: 10.17912/micropub.biology.000726

Abstract

TLN-1/talin is a conserved focal adhesion protein linking integrin to actin. In C. elegans, TLN-1 is expressed in muscles and gonadal sheath cells. A CRISPR-generated TLN-1(W387A) allele, predicted to alter integrin binding, caused mild motility and ovulation defects but no major actin structural changes. These results indicate that residue W387 in TLN-1 has limited impact on integrin binding and muscle organization in vivo.

Keywords

talin, integrin, ovulation, motility, C. elegans

Citation

Sadeghian, F., Ibrahim, I., Ravichandran, L., Henderson, G., Acharya, A., Wang, L., Lee, M., & Cram, E. J. (2023). An integrin binding motif in TLN-1/talin plays a minor role in motility and ovulation. microPublication Biology. https://doi.org/10.17912/micropub.biology.000726

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